Recent Publications

Endothelial (Dys)function


Friedrichs P, Schlotterer A, Sticht C,Kolibabka M, Wohlfart P, Dietrich A, Linn T, Molema G, Hammes HP. Hyperglycaemic memory affects the neurovascular unitof the retina in a diabetic mouse model. Diabetologia.2017 Jul;60(7):1354-1358.


Moser J, van Ark J, van Dijk MC, Greiner DL, Shultz LD, van Goor H, Hillebrands JL. Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury.  Sci Rep. 2016 Oct 19;6:35387.






Koning NJ, de Lange F, van Meurs M, Jongman RM, Ahmed Y, Schwarte LA, van Nieuw Amerongen GP, Vonk ABA, Niessen HW, Baufreton C, Boer C. Reduction of vascular leakage by imatinib is associated with preserved microcirculatory perfusion and reduced renal injury markers in a rat model of cardiopulmonary bypass.  Br J Anaesth. 2018 Jun;120(6):1165-1175.


Yan R, van Meurs M, Popa ER, Li R, Zwiers PJ, Zijlstra JG, Moser J, Molema G. Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade. Shock. 2018 Feb 21. doi: 10.1097/SHK.0000000000001126.


 Trieu M, van Meurs M, van Leeuwen ALI, Van Slyke P, Hoang V, Geeraedts LMG Jr, Boer C, van den Brom CE. Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitiation Requirements in Hemorrhagic Shock.  Anesthesiology. 2018 Feb;128(2):361-374.


Aslan A, van Meurs M, Moser J, Popa ER, Jongman RM, Zwiers PJ, Molema G, Zijlstra JG. Organ-Specific Differences in Endothelial Permeability-Regulating Molecular Responses in Mouse and Human Sepsis. Shock. 2017 Jul;48(1):69-77.


Zonneveld R, Jongman RM, Juliana A, Zijlmans W, Plötz F, Molema G, van Meurs M. Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns. Shock. 2017 Dec;48(6):638-643.


Mencke R, Harms G, Moser J, van Meurs M, Diepstra A, Leuvenink HG, Hillebrands JL. Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease.  JCI Insight. 2017 Oct 19;2(20). pii: 94375.


Yan R, van Meurs M, Popa ER, Jongman RM, Zwiers PJ, Niemarkt AE, Kuiper T, Kamps JA, Heeringa P, Zijlstra JG, Molema G, Moser J. Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB. J Innate Immun. 2017;9(6):546-560.


Moser J, van Meurs M, Zijlstra JG.  There Are More Things in Heaven and Earth, Horatio, Than Are Dreamt of in Our Philosophy. Crit Care Med. 2017 Jul;45(7):e740.


Targeted Drug Delivery


Li R, Kowalski PS, Morselt HWM, Schepel I, Jongman RM, Aslan A, Ruiters MHJ, Zijlstra JG, Molema G, van Meurs M, Kamps JAAM. Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia. PLoS One. 2018 May 15;13(5):e0196976.


 Choi M, Schreiber A, Eulenberg-Gustavus C, Scheidereit C, Kamps J, Kettritz R.  Endothelial NF-κB Blockade Abrogates ANCA-Induced GN. J Am Soc Nephrol. 2017 Nov;28(11):3191-3204.


Gholizadeh S, Visweswaran GRR, Storm G, Hennink WE, Kamps JAAM, Kok RJ. E-selectin targeted immunoliposomes for rapamycin

delivery to activated endothelial cells.  Int J Pharm. 2017 Oct 13. pii: S0378-5173(17)30997-3.

Gholizadeh S, Kamps JAAM, Hennink WE, Kok RJ. PLGA-PEG nanoparticles for targeted delivery of the mTOR/PI3kinase inhibitor dactolisib to inflamed endothelium.  Int

J Pharm. 2017 Oct 16. pii: S0378-5173(17)31002-5.


 Smink AM, Li S, Swart DH, Hertsig DT, de Haan BJ, Kamps JAAM, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, Lakey JRT, de Vos P. J Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia. Biomed Mater Res A. 2017 Sep;105(9):2533-2542.




Vasculitis Research UMCG


Heeringa P, Rutgers A, Kallenberg CGM. The net effect of ANCA on neutrophil extracellular trap formation. Kidney Int. 2018 Jul;94(1):14-16.


Heeringa P, Alan Little M. Releasing the complement brakes: is myeloperoxidase the missing link between factor H and C5a in anti-neutrophil cytoplasmic antibody vasculitis?

Rheumatology. 2018 May 10.


 Jiemy WF, Heeringa P, Kamps JAAM, van der Laken CJ, Slart RHJA, Brouwer E. Positron emission tomography (PET) and single photon


emission computed tomography (SPECT) imaging of macrophages in large vessel vasculitis: Current status and future prospects.

Autoimmun Rev. 2018 Jul;17(7):715-726.


van der Geest KSM, Sandovici M, van Sleen Y, Sanders JS, Bos NA, Abdulahad WH, Stegeman CA, Heeringa P, Rutgers A, Kallenberg CGM, Boots AMH, Brouwer E. What is the Current Evidence for Disease Subsets in Giant Cell Arteritis? Arthritis Rheumatol. 2018 Apr 12.


Hid Cadena R, Abdulahad WH, Hospers GAP, Wind TT, Boots AMH, Heeringa P, Brouwer E.  Checks and Balances in Autoimmune Vasculitis. Front Immunol. 2018 Feb 22;9:315.


Dekkema GJ, Abdulahad WH, Bijma T, Moran SM, Ryan L, Little MA, Stegeman CA, Heeringa P, Sanders JF. Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study. Nephrol Dial Transplant. 2018 Mar 1. doi: 10.1093/ndt/gfy018.


von Borstel A, Sanders JS, Rutgers A, Stegeman CA, Heeringa P, Abdulahad WH. Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides. Autoimmun Rev. 2018 Apr;17(4):413-421.


Rutgers A, van den Brom RRH, Hospers GAP, Heeringa P, Brouwer E. Systemic vasculitis developed after immune checkpoint inhibition.  Arthritis Care Res . 2017 Dec 1. doi: 10.1002/acr.23481.

van der Geest KSM, Brouwer E, Sanders JS, Sandovici M, Bos NA, Boots AMH, Abdulahad WH, Stegeman CA, Kallenberg CGM, Heeringa P, Rutgers A. Towards precision medicine in ANCA-associated vasculitis. Rheumatology. 2017 Oct 17. doi: 10.1093/rheumatology/kex367.


Land J, Lintermans LL, Stegeman CA, Muñoz-Elías EJ, Tarcha EJ, Iadonato SP, Heeringa P, Rutgers A, Abdulahad WH. Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis.  Front Immunol. 2017 Sep 26;8:1205. doi: 10.3389/fimmu.2017.01205. eCollection



Ingrid (G.) Molema

Professor of Life Sciences / EBVDT Group Leader

University Medical Center Groningen (UMCG)

Dept. Pathology and Medical Biology, Medical Biology section


Room T2.228

Internal postal code: EA11

Hanzeplein 1

9713 GZ Groningen

The Netherlands

Telephone: +31-50-3610115

Fax: +31-50-3619911