The research in the laboratory for Endothelial Biomedicine & Vascular Drug Targeting focuses on understanding organ specific, microvascular endothelial cell behaviour in (inflammatory) diseases and cancer, and on the development of therapeutic strategies to selectively interfere with endothelial cell engagement in these diseases.
Three lines of research are explored in an integrated manner:
Unraveling of the molecular responses underlying microvascular endothelial cell activation and dysfunction and their relation to leukocyte accumulation in inflammatory conditions and cancer, from the clinic to bench and back.
Studying the molecular consequences of drug treatment on the microvasculature as well as in selected microvascular segments in diseased organs and their relation to disease progression.
Development of targeted drug delivery strategies that selectively interfere with endothelial cell engagement in diseased tissues.
More information on these topics, as well as on currently active projects, the participating scientists and research assistants, and an overview of relevant publications can be found by clicking on the links in the menu above.